Expression of a modified astrocytic glutamate transporter alleviates Huntington hypokinesia, promotes synaptic glutamate clearance and counteracts potentially adverse EAAT2 interactions
Stefan Hirschberg, Anton Dvorzhak, Seyed M. A. Rasooli-Nejad, Svilen D. Angelov, Marieluise Kirchner, Philip Mertins, Gisela Lättig-Tünnemann, Christoph Harms, Dietmar Schmitz, Rosemarie Grantyn
This study shows that modifying the C-terminal of EAAT2 in a Huntington's disease mouse model reduces hypokinesia symptoms by improving glutamate clearance and reversing some HD-induced changes in EAAT2 interactions.
bioRxiv · Sep 17, 2020 · PreprintNeuroscience