Iswar K. Hariharan

Coding region changes in the Hippo pathway component YAP1 contribute to body size differences among mammalian species

This study identifies coding region changes in YAP1 that contribute to body size differences among rodents by showing increased growth-promoting activity in capybara YAP1 compared to mouse and vole YAP1.

Single-cell transcriptomics of X-ray irradiated Drosophila wing discs reveals heterogeneity related to cell-cycle status and cell location

This study uses single-cell RNA-seq to analyze X-ray irradiation effects on Drosophila wing discs, revealing regional and intra-regional gene expression heterogeneity.

The cell adhesion molecule Echinoid promotes tissue survival and separately restricts tissue overgrowth in Drosophila imaginal discs

This study identifies Echinoid's dual role in promoting tissue survival via Diap1 and restricting overgrowth by arresting growth at final size in Drosophila imaginal discs.

Coordinated growth of linked epithelia is mediated by the Hippo pathway

The paper shows that the Hippo pathway enables the peripodial epithelium to adapt its growth to the disc proper in Drosophila, using mechanical signals rather than morphogens.

Critical genetic program for Drosophila imaginal disc regeneration revealed by single-cell analysis

The paper identifies regeneration-specific cell populations in Drosophila wing discs using single-cell transcriptomics and shows that Ets21C controls regeneration-promoting genes.

Single-cell transcriptomics of the Drosophila wing disc reveals instructive epithelium-to-myoblast interactions

The paper uses single-cell transcriptomics to study Drosophila wing disc development, identifying gene expression patterns and signaling interactions between epithelial cells and muscle precursors.

Membrane potential regulates Hedgehog signaling and compartment boundary maintenance in the Drosophila wing disc

The paper shows membrane depolarization and Hedgehog signaling mutually reinforce compartment boundary maintenance in the Drosophila wing disc.

Regenerative capacity in Drosophila imaginal discs is controlled by damage-responsive, maturity-silenced enhancers

The paper identifies damage-responsive, maturity-silenced enhancers that control regenerative capacity in Drosophila imaginal discs and shows their regulation by chromatin factors.

The transcriptional co-repressor CtBP is a negative regulator of growth that antagonizes the Yorkie and JNK/AP-1 pathways

The paper identifies CtBP as a negative regulator of growth that antagonizes Yorkie and JNK/AP-1 pathways by restricting bantam microRNA expression.

The BMP2/4 ortholog Dpp functions as an inter-organ signal that regulates developmental timing in Drosophila

The paper shows Dpp acts as a systemic signal from peripheral tissues to the prothoracic gland to regulate developmental timing in Drosophila by modulating ecdysone biosynthesis.