Daniel J. McKay

The paper shows Mi-2 and E93 coordinate cell cycle exit with terminal differentiation by decommissioning enhancers at key genes in Drosophila.

This study shows that availability of histone H3 is more critical for development than the specific subtype (H3.2 vs H3.3) in Drosophila.

The paper shows that H3.2K4 antagonizes Polycomb group activity and promotes target gene expression in vivo.

The paper develops a new genetic platform in Drosophila to improve spatiotemporal manipulation of histone function through CRISPR and synthetic gene arrays.

This study shows that the Drosophila BAP complex, a SWI/SNF remodeler, constrains enhancer activity during wing development, preventing ectopic sensory structures and hyperactivation of the Delta gene.

The paper shows that reduced canonical histone gene copy number in Drosophila disrupts Polycomb function, leading to developmental defects and ectopic sex combs.

The paper introduces a tissue dissociation method optimized for ATAC-seq and CUT&RUN in Drosophila pupal tissues to study chromatin accessibility and histone modifications during metamorphosis.

The paper shows that H3.2 and H3.3 K36 residues have distinct roles in maintaining Polycomb silencing of Hox genes through different mechanisms, enabling development.

The paper investigates how EcR mediates tissue-specific ecdysone responses in Drosophila, finding that EcR functions both repressively and activating, binds tissue-specifically, and does not control chromatin accessibility.

This study shows that Set8/KMT5A and H4K20me1 have distinct roles in Drosophila development, with non-catalytic functions of Set8 and H4K20me1 contributing to viability and phenotypic differences.

The paper introduces an R package called memes that provides a seamless interface to the MEME Suite for motif analysis, leveraging R/Bioconductor data structures and visualization tools.

This study shows that the transcription factor E93 regulates enhancer activity and chromatin accessibility during Drosophila wing development, accelerating the developmental program by altering enhancer competence.

The paper identifies damage-responsive, maturity-silenced enhancers that control regenerative capacity in Drosophila imaginal discs and shows their regulation by chromatin factors.

The paper shows that chromatin accessibility changes at cell cycle genes enforce cell cycle exit during terminal differentiation in Drosophila wing cells, independent of DREAM complex function.

This study investigates the role of the nuclear receptor EcR in mediating ecdysone responses during Drosophila wing development, revealing its widespread and dynamic gene regulatory functions.

This paper investigates how Wnt signaling affects the localization, molecular size, and activity of the beta-catenin destruction complex in Drosophila embryos, revealing new insights into complex regulation.

The paper identifies and evaluates enhancer activity in Tribolium castaneum using chromatin profiling and a cross-species reporter assay system.

The paper uses high-depth TSS mapping in D. melanogaster to identify novel initiation events and characterize enhancer-associated RNAs (eRNAs) in a developmental context.

The paper investigates the functional roles of K9 modifications on variant and canonical histone H3 in Drosophila, showing overlapping but distinct contributions to chromatin structure and gene regulation.

This study replaces H3K36 with arginine in Drosophila to show H3K36 methylation maintains transcriptome fidelity through post-transcriptional mechanisms involving polyadenylation.