An integrated picture of the structural pathways controlling the heart performance
Ilaria Morotti, Marco Caremani, Matteo Marcello, Irene Pertici, Caterina Squarci, Pasquale Bianco, Theyencheri Narayanan, Gabriella Piazzesi, Massimo Reconditi, Vincenzo Lombardi, Marco Linari
The paper revises the mechanosensing hypothesis of heart function using X-ray diffraction data and cryo-EM structures, identifying structural changes in thick filaments that modulate motor activation and heart performance.
Proceedings of the National Academy of Sciences · Dec 4, 2024Peer-reviewedPhysiology