Caterina Squarci

This study shows that phosphorylation of cardiac myosin regulatory light chain (RLC) is spatially controlled and modulates mechano-sensing in cardiac thick filaments.

This study investigates danicamtiv's effects on cardiac myosin mechanics and shows it enhances contraction by altering crossbridge kinetics and thin filament activation.

The paper revises the mechanosensing hypothesis of heart function using X-ray diffraction data and cryo-EM structures, identifying structural changes in thick filaments that modulate motor activation and heart performance.