Revathi Balasubramanian

Molecular profiling implicates immune-driven adaptive homeostasis in maintaining intraocular pressure with age

The paper uses single-cell RNA sequencing to identify age-related immune remodeling in ocular outflow tissues that may help maintain intraocular pressure.

An Integrated muti-omics cell atlas of the human trabecular meshwork and ciliary body

The paper creates a multi-omics atlas of human trabecular meshwork and ciliary body cells, identifying cell types and regulatory programs linked to glaucoma.

Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment

The paper identifies mitochondrial dysfunction in a glaucoma model using single-cell analysis and shows that vitamin B3 treatment protects against IOP elevation.

Single-Cell Characterization of Anterior Segment Development: Cell Types, Pathways, and Signals Driving Formation of the Trabecular Meshwork and Schlemm's Canal

The paper uses single-cell transcriptomics to characterize anterior segment development, identifying cell types, pathways, and signaling networks in trabecular meshwork and Schlemm's canal formation.

Resident Tissue Macrophages Govern Intraocular Pressure Homeostasis

The paper identifies resident tissue macrophages as critical for maintaining intraocular pressure homeostasis by regulating extracellular matrix turnover in the trabecular meshwork.

Transcriptomic profiling of Schlemm's canal cells reveals a lymphatic-biased identity and three major cell states

The paper performs transcriptomic analyses of Schlemm's canal endothelial cells to reveal their lymphatic identity, three major cell states, and interactions with trabecular meshwork cells.

CyclinD2-mediated regulation of neurogenic output from the retinal ciliary margin is perturbed in albinism

The paper investigates how CyclinD2 regulates RGC neurogenesis in the mouse ciliary margin zone and shows its disruption in albinism leads to impaired binocular vision.

Phase transition specified by a binary code patterns the vertebrate eye cup

The paper shows that FGF and Wnt signaling gradients determine phase transitions in vertebrate eye cup development, specifying cell fates through their combinatorial code.

Genetic background modifies vulnerability to glaucoma related phenotypes in Lmx1b mutant mice

This study shows that genetic background affects the severity of glaucoma-related phenotypes in Lmx1b mutant mice, identifies a modifier locus on Chromosome 18, and provides strains with varying phenotypes.

Deficient FGF signaling in the developing peripheral retina disrupts ciliary margin development and causes aniridia

This study shows that FGF signaling is essential for ciliary margin development in the retina, with its disruption causing aniridia by altering the boundary between the central retina and the ciliary margin.