Cancer BiologyCancer ResearchPeer-reviewed
Deficiency in POLE exonuclease causes synthetic lethality in highly aneuploid cancer cells
Eun‐Jung Kim, Dexter X. Jin, Alejandro Martinez Chibly…·Meng He
The paper identifies synthetic lethality between POLE exonuclease deficiency and high aneuploidy in cancer cells, suggesting POLE inhibition as a therapeutic strategy for aneuploid tumors.
DOI 10.1158/0008-5472.can-25-3977