Developing inhibitors of the guanosine triphosphate hydrolysis accelerating activity of Regulator of G protein Signaling-14
Percy S. Agogo-Mawuli, Isra Sadiya, Tigran M. Abramyan, Dustin E. Bosch, Kyle A. Emmitte, Luis M. Colón-Pérez, Mickey Kosloff, David Peter Siderovski
This paper identifies and validates non-covalent inhibitors of RGS14 GAP activity using structure-guided virtual screening and machine learning, showing improved potency and CNS penetration.
Journal of Biological Chemistry · Aug 22, 2025Peer-reviewedPharmacology & Toxicology