Author

Claire Crafter

AstraZeneca (United Kingdom)ORCID 0000-0001-6566-0868Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Aldo Segura‐CabreraiD· 1 shared Alexandra BeckiD· 1 shared Andrew R. LeachiD· 1 shared Andrew S. Barthorpe· 1 shared Ben S. SiddersiD· 1 shared Caitlin HalliD· 1 shared Charlotte TolleyiD· 1 shared Clare PaciniiD· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperSystems Biology

Aldo Segura‐CabreraORCID

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2 papers

Recent·Most cited

Systems BiologyMolecular Systems BiologyPeer-reviewedJul 1, 2020

Drug mechanism-of-action discovery through the integration of pharmacological and CRISPR screens

Emanuel Gonçalves, Aldo Segura‐Cabrera, Clare Pacini…·Mathew J. Garnett

This study integrates drug sensitivity data with CRISPR screens to identify drug mechanisms and biomarkers for cancer therapy.

101 citationstop 2%

humanCRISPR screen

𝕏 PostBluesky

Molecular BiologybioRxivPreprintOct 4, 2019

Assembly of novel, nuclear dimers of the PI3-Kinase regulatory subunits underpins the pro-proliferative activity of the Cdc42-activated tyrosine kinase, ACK

Natasha S. Clayton, Millie Fox, Jose J. Vicenté-Garcia…·Darerca Owen

The paper shows ACK promotes cell proliferation by stabilizing p85 regulatory subunits and forming nuclear dimers, which may contribute to oncogenesis through novel PI3-Kinase regulation.

3 citations

humanexperimental assay

𝕏 PostBluesky