Charlotte Tolley

Recapitulating whipworm development in vitro using caecaloids

This study establishes an in vitro system using caecaloids to recapitulate whipworm development, showing that larvae develop anatomical features and growth patterns similar to in vivo conditions.

Host microbiome determines host specificity of the human whipworm, Trichuris trichiura

This study shows that the human whipworm's host specificity is driven by the host microbiome, using a humanized-microbiota mouse model and metagenomic analysis.

Hatching of whipworm eggs induced by bacterial contact is serine-protease dependent

This study identifies serine proteases as key mediators of whipworm egg hatching induced by bacterial contact, revealing bacterial and larval enzyme interactions.

Drug mechanism-of-action discovery through the integration of pharmacological and CRISPR screens

This study integrates drug sensitivity data with CRISPR screens to identify drug mechanisms and biomarkers for cancer therapy.