Author

Darerca Owen

University of CambridgeORCID 0000-0003-0978-5425Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biophysics· 1 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Helen R. MottiD· 3 shared Claire CrafteriD· 1 shared Courtney M. SchroederiD· 1 shared Georgios SophocleousiD· 1 shared Hanlu CheniD· 1 shared Jessica CorryiD· 1 shared Jonathan I. Wilde· 1 shared Jose J. Vicenté-Garcia· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

Helen R. MottORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cell BiologyThe Journal of Cell BiologyPeer-reviewedOct 28, 2026

Kinase interplay centered on two regulatory elements compartmentalizes the checkpoint protein Lte1 in S. cerevisiae

Marco Geymonat, Qiuran Peng, Hanlu Chen…·Marisa Segal

The paper identifies two regulatory elements in Lte1 that coordinate kinase activity to compartmentalize Lte1 at the bud cortex in S. cerevisiae, ensuring proper mitotic exit.

DOI 10.1083/jcb.202510036

yeastproteomics

𝕏 PostBluesky

BiophysicsJournal of Biological ChemistryPeer-reviewedApr 24, 2026

Structural basis of the protein kinase PKN1 HR1 domain oligomerization and differential regulation by RhoA and Rac1

Georgios Sophocleous, Darerca Owen, Helen R. Mott

This study investigates the structural roles of PKN1 HR1 domains in oligomerization and their differential regulation by RhoA and Rac1.

DOI 10.1016/j.jbc.2026.112203

humanprotein structure

𝕏 PostBluesky

Molecular BiologybioRxivPreprintOct 4, 2019

Assembly of novel, nuclear dimers of the PI3-Kinase regulatory subunits underpins the pro-proliferative activity of the Cdc42-activated tyrosine kinase, ACK

Natasha S. Clayton, Millie Fox, Jose J. Vicenté-Garcia…·Darerca Owen

The paper shows ACK promotes cell proliferation by stabilizing p85 regulatory subunits and forming nuclear dimers, which may contribute to oncogenesis through novel PI3-Kinase regulation.

3 citations

humanexperimental assay

𝕏 PostBluesky