Author

Zhaojie Chai

Brown UniversityORCID 0000-0001-6571-247XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:deep learning· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:machine learning (classical)· 1 Assay:proteomics· 1

Frequent Co-Authors

George Em KarniadakisiD· 2 shared Guansheng LiiD· 1 shared Mélanie FrancoiD· 1 shared Nazanin Ahmadi DaryakenariiD· 1 shared Papa Alioune NdouriD· 1 shared Philippe ConnesiD· 1 shared Pierre A. BuffetiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 16 mutual co-author links

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2 shared papersBiophysics

George Em KarniadakisORCID

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2 papers

Recent·Most cited

BiophysicsPNAS NexusPeer-reviewedSep 30, 2026

A Multiscale Signaling--Biophysical Framework Reveals Mechanisms of Macrophage-Mediated RBC Clearance in Sickle Cell and Gaucher Disease

Zhaojie Chai, Nazanin Ahmadi Daryakenari, George Em Karniadakis

This paper develops a multiscale modeling framework to study macrophage-mediated RBC clearance in sickle cell disease and Gaucher disease, revealing altered signaling and biophysical mechanisms.

1 citation

humanproteomics

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BiophysicsPLoS Computational BiologyPeer-reviewedSep 10, 2025

In silico biophysics and rheology of blood and red blood cells in Gaucher Disease

Zhaojie Chai, Guansheng Li, Papa Alioune Ndour…·George Em Karniadakis

This study uses DPD simulations to analyze how altered RBC properties in Gaucher Disease affect blood viscosity and bone health through three shear rate domains.

8 citationstop 4%

humandeep learning

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