Author

Philippe Connes

Lyon 1 UniversitéORCID 0000-0002-9232-0268Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Élie NaderiD· 2 shared Angelo D'AlessandroiD· 1 shared Bita Asghariastanehei· 1 shared Cyril Castelbou· 1 shared Daniel StephensoniD· 1 shared Émeric StaufferiD· 1 shared Francesca Isabelle CendaliiD· 1 shared Franciele de LimaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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2 shared papersPharmacology & Toxicology

Élie NaderORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Otenabant is a Selective Antagonist of Human PIEZO1

Vincent Jaquet, Reeta Penttinen, Gorane Rodríguez-Urquirizar, Cyril Castelbou, Yves Cambet, Nicolas Rosa, Mathilde Bourdin, Bita Asghariastanehei, Franciele de Lima, Marie Martin, Élie Nader, Selma Angèlica Serra, José M. Fernández‐Fernández, Nicoletta Murciano, Philippe Connes, , Nicolas Demaurex

The paper identifies Otenabant, a CB1 antagonist, as a potent and selective PIEZO1 inhibitor through high-throughput screening and validates its effects across multiple assays.

bioRxiv · Apr 30, 2026 · PreprintPharmacology & Toxicology

Long-Distance Trail Running Induces Inflammatory-Associated Protein, Lipid, and Purine Oxidation in Red Blood Cells

Travis G. Nemkov, Émeric Stauffer, Francesca Isabelle Cendali, Daniel Stephenson, Élie Nader, Mélanie Robert, Sarah Skinner, Monika Dzieciątkowska, Kirk Charles Hansen, Paul Robach, Guillaume Y. Millet, Philippe Connes, Angelo D'Alessandro

This study shows that long-distance trail running causes inflammation, lipid, and purine oxidation in red blood cells, indicating systemic inflammation and metabolic changes as key factors in RBC damage.

Blood Red Cells & Iron · Feb 18, 2026Peer-reviewedBiochemistry

In silico biophysics and rheology of blood and red blood cells in Gaucher Disease

Zhaojie Chai, Guansheng Li, Papa Alioune Ndour, Philippe Connes, Pierre A. Buffet, Mélanie Franco, George Em Karniadakis

This study uses DPD simulations to analyze how altered RBC properties in Gaucher Disease affect blood viscosity and bone health through three shear rate domains.

PLoS Computational Biology · Sep 10, 2025Peer-reviewedBiophysics