Vasavi Sundaram

This study shows that genetic background and environmental factors determine the trajectory of cancer evolution in mice, with distinct mutational paths despite similar final tumor states.

This study investigates how germline and somatic genetic variations affect mitochondrial DNA content, mutation patterns, and gene expression in liver tumors across four mouse strains.

The paper investigates how strand-asymmetric processes like replication and transcription influence DNA damage, repair, and mutagenesis, revealing mechanisms that shape cancer genome evolution.

The paper tests the regulatory activity of human LTR18A transposable elements and finds they have lost activity over time due to mutations in AP-1 and C/EBP motifs.

This paper introduces CNAqc, a toolset for validating clonal and subclonal copy number alterations in bulk tumor sequencing by addressing tumor purity, ploidy, and heterogeneity using simulations and single-cell data.