TDP-43 toxic gain of function links ALS, FTD and Alzheimers Disease through splicing dysregulation
Welmoed van Zuiden, Thea Deborah Meimoun, Bar Chen, Aviad Siany, Bar Abarbanel, Lihi Moshe, Nancy‐Sarah Yacovzada, Emmanuel Amzallag, Aleksandar Rajkovic, Liat Alyagor, Eviatar Weizman, Manuela Neumann, Colin Smith, Karina McDade, Andrew Strange, , Eran Hornstein
This study identifies TDP-43-driven splicing dysregulation as a common mechanism in ALS, FTD, and Alzheimer's disease, linking them through mis-spliced mRNAs like APP.
bioRxiv · Apr 20, 2025 · PreprintNeuroscience