Andrew M. Davidson

The paper demonstrates that cAMP pathway activation induces LTD in Drosophila mushroom body synapses, contradicting the general role of cAMP in LTP and revealing antagonistic actions between cAMP and cGMP pathways.

This study identifies a neuromodulatory mechanism in Drosophila that enhances stimulus-specific olfactory learning by suppressing unwanted neural responses through axo-axonic connections mediated by mAChR-B.