Toshihide Hige

Natural non-coding pumilio variants retune value-coding interneurons to bias Drosophila oviposition choices

The paper shows how natural variants in the pumilio gene alter neural circuits in Drosophila to influence oviposition choices by affecting sodium channel expression.

Cyclic nucleotide-induced bidirectional long-term synaptic plasticity in Drosophila mushroom body

The paper demonstrates that cAMP pathway activation induces LTD in Drosophila mushroom body synapses, contradicting the general role of cAMP in LTP and revealing antagonistic actions between cAMP and cGMP pathways.

A lightweight data-driven spiking neural network model of Drosophila olfactory nervous system with dedicated hardware support

Neural circuit mechanisms for transforming learned olfactory valences into wind-oriented movement

The paper identifies a neuronal circuit in Drosophila that transforms learned olfactory valences into wind-oriented movement by integrating inputs from memory compartments.

Hierarchical architecture of dopaminergic circuits enables second-order conditioning in Drosophila

The paper identifies a feedforward circuit between dopamine subsystems in Drosophila that is essential for second-order conditioning, mediated by a key interneuron.

Lateral Axonal Modulation is Required for Stimulus-Specific Olfactory Conditioning in Drosophila

This study identifies a neuromodulatory mechanism in Drosophila that enhances stimulus-specific olfactory learning by suppressing unwanted neural responses through axo-axonic connections mediated by mAChR-B.