Leila Kushan

Lifespan Normative Modeling of Brain Microstructure

This paper develops a lifespan normative model of brain white matter microstructure using diffusion MRI data from 54,583 individuals, enabling detection of microstructural deviations in diseases like Alzheimer's and 22q11.2 deletion syndrome.

Convergent and Divergent Cerebellar Alterations in 22q11.2 Copy Number Variants

This study compares cerebellar volume changes in 22q11.2 deletion and duplication carriers, finding divergent structural and behavioral associations.

Gene dosage effects of 22q11.2 copy number variants on in-vivo measures of white matter axonal density and dispersion

Synaptic-dependent developmental dysconnectivity in 22q11.2 deletion syndrome

This study investigates developmental dysconnectivity in 22q11.2 deletion syndrome using a cross-species approach, finding age-specific fMRI connectivity changes with synaptic origins.

Unique functional neuroimaging signatures of genetic versus clinical high risk for psychosis

The paper compares functional brain measures between 22qDel and CHR cohorts, finding distinct patterns of connectivity and variability disruptions.

Using rare genetic mutations to revisit structural brain asymmetry

The paper investigates how rare genetic mutations affect brain asymmetry by analyzing CNVs in a cohort of individuals and linking genetic alterations to brain structure and function.

Effects of Gene Dosage and Development on Subcortical Nuclei Volumes in Individuals with 22q11.2 Copy Number Variations

This study examines how 22q11.2 copy number variations affect subcortical brain volumes and their development across different age groups.

Longitudinal development of thalamocortical functional connectivity in 22q11.2 deletion syndrome

This study examines age-related changes in thalamocortical functional connectivity in 22q11.2 deletion syndrome and typically developing controls, finding altered developmental trajectories in specific networks.

Subcortical brain alterations in carriers of genomic copy number variants

This study examines subcortical brain alterations in CNV carriers across multiple neuropsychiatric disorders, finding shared and distinct patterns of structural changes.

Rare CNVs and phenome-wide profiling: a tale of brain-structural divergence and phenotypical convergence

The paper investigates how eight rare CNVs affect brain structure and phenotypes across 534 carriers, finding structural divergence and phenotypic convergence despite different genetic origins.

Neuropsychiatric mutations delineate functional brain connectivity dimensions contributing to autism and schizophrenia

The paper examines how CNVs in 16p11.2 and 22q11.2 affect functional brain connectivity in neuropsychiatric disorders, identifying shared dysconnectivity patterns across ASD, SZ, and deletions.

Neuropsychiatric copy number variants exert shared effects on human brain structure

The paper examines the effects of neuropsychiatric CNVs on brain structure using neuroimaging data and identifies shared anatomical patterns across multiple CNVs.

Reciprocal Disruptions in Thalamic and Hippocampal Resting-State Functional Connectivity in Youth with 22q11.2 Deletions