Shubha Tole

This study shows that constitutive β-Catenin activation in cortical hem progenitors disrupts CR cell identity by preventing the Tbr2+ stage.

This study shows that loss of Lhx2 increases astrocyte proliferation in upper cortical layers and induces reactive gliosis-like signatures without injury.

This study shows FOXG1 regulates gliogenesis in the mouse neocortex through distinct roles in progenitors and postmitotic neurons, modulating the FGF signalling pathway to control astrocyte and oligodendrocyte production.

The paper investigates PRDM16's role in human brain development by analyzing a patient mutation and cortical organoids, revealing its collaboration with LHX2 in gene regulation.

This study shows that β-CATENIN is essential for organizing fimbrial glia and guiding dentate gyrus development, but not for CR cell positioning.

This study shows that constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial identity in mice and human stem cell-derived organoids.

This study shows that loss of Lhx2 in cortical progenitors leads to premature thalamocortical innervation due to altered subplate neuron development.

The paper shows that the Lhx2-Ldb1 interaction is conserved in regulating hippocampal development and cell fate in mice.