Deepanjali Dwivedi

The paper develops a cross-species enhancer-AAV toolkit for targeting specific cell types in the basal ganglia across species, validated in mouse and macaque.

The paper evaluates computational methods for predicting cell type-specific enhancers in the mouse cortex using in vivo validation data and finds that open chromatin and sequence models improve prediction accuracy.

The paper presents an enhancer AAV toolbox for targeting and perturbing striatal cell types and circuits in mice, with validated specificity and cross-species applicability.

The paper identifies enhancer-AAV tools for specific neuronal subtypes and validates them across species.

The paper develops a toolkit of transgenic mouse lines and enhancer AAVs for selective targeting of cortical cell populations using transcriptomic and epigenomic data.

The paper shows that metabotropic signaling in somatostatin interneurons eliminates transient thalamocortical inputs during development, affecting adult exploratory behavior.

This study disrupts cholinergic retinal waves in mice and shows impaired visual cortex development and function, including altered retinotopy and sensory processing.

The paper identifies cell-type specific circuits formed by subtypes of somatostatin interneurons in the cortex through genetic targeting and connectivity analysis.

The paper maps presynaptic inputs to PV and SST cortical interneurons across cortical areas, revealing region-specific developmental patterns and differential vulnerability to neurodevelopmental disorders.

This study shows that loss of Lhx2 in cortical progenitors leads to premature thalamocortical innervation due to altered subplate neuron development.

This study shows that FMRP KO in mice leads to increased spiking variability in CA1 neurons of adult hippocampus but not juveniles, linked to elevated SK currents.