Tuli Pramanik

Functional divergence of WWC family proteins in human endothelial cells

This study identifies distinct roles for WWC2 and WWC3 in human endothelial cells, showing WWC3's dominance in Hippo signaling and WWC2's role in VEGF signaling, with both affecting EC proliferation and migration.

Transient architecture of the embryonic pancreas determines endocrine mass

This study shows that transient 3D epithelial architecture in the embryonic pancreas instructs lineage allocation and endocrine cell mass formation through Merlin-dependent membrane trafficking.

Endothelial adaptation to complex flow patterns in a novel in vitro model predicted by computational fluid dynamics

This paper develops an in vitro model of complex flow patterns using engineered geometries and computational fluid dynamics to study endothelial cell adaptation to hemodynamic forces.

Lats1/2 are essential for developmental vascular remodeling and biomechanical adaptation to shear stress

This paper shows that Lats1/2 are essential for vascular remodeling and response to shear stress in embryonic endothelial cells, leading to vascular defects and embryonic lethality.

An early cortical progenitor-specific mechanism regulates thalamocortical innervation

This study shows that loss of Lhx2 in cortical progenitors leads to premature thalamocortical innervation due to altered subplate neuron development.