Author

Lakshmi Mahendrawada

Fred Hutch Cancer CenterORCID 0000-0001-6605-1132Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:yeast· 2 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Linda WarfieldiD· 2 shared Rafał DonczewiD· 2 shared Steven HahniD· 2 shared

Activity by Year

2022-2025 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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2 shared papersGenomics

Linda WarfieldORCID

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2 papers

Recent·Most cited

GenomicsNaturePeer-reviewedApr 16, 2025

Surprising connections between DNA binding and function for the near-complete set of yeast transcription factors

Lakshmi Mahendrawada, Linda Warfield, Rafał Donczew, Steven Hahn

The paper maps DNA binding and regulatory targets for nearly all yeast transcription factors, revealing that TF binding does not always correlate with gene regulation and many TFs have dual functions.

102 citationstop 1%

yeastDNA methylation

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Molecular BiologyMolecular CellPeer-reviewedOct 7, 2022

Mediator is broadly recruited to gene promoters via a Tail-independent mechanism

Linda Warfield, Rafał Donczew, Lakshmi Mahendrawada, Steven Hahn

The paper investigates the genome-wide roles of yeast Mediator (MED) by depleting its activator-binding domain and finds that MED is directly recruited to most promoters independently of enhancers and activators.

23 citations

yeastChIP-seq

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