Kristy Welshhans

This study shows that cellular morphology and motility defects are consistent in Down syndrome across different cell types, despite variable adhesion mechanism changes.

This study identifies an axon-intrinsic loop where REG3A promotes KHSRP translation, slowing nerve regeneration through localized mRNA synthesis and Ca2+ signaling.

This study shows that paxillin is not required for axonal growth in cortical neurons during development, as knockout mice showed no significant changes in axon length or morphology under basal conditions.

The paper shows laminin and BDNF synergistically increase local translation in axonal growth cones, with isoform-specific effects on translation and axon guidance.

This paper shows that disrupting G3BP1 granules promotes axon regeneration in both CNS and PNS injuries, suggesting a therapeutic strategy for neural repair.

This study shows RACK1 is required for BDNF-induced local translation of β-actin mRNA at growth cone point contacts, which regulates axon guidance and development.

This study examines interhemispheric connectivity in Ts65Dn mice, finding reduced hippocampal commissure volume at birth and impaired axon growth in vitro, suggesting early developmental defects may be targets for therapeutic intervention.