Marco Todisco

The paper shows that mRNA sequences have evolved to minimize self-association, maintaining transcriptome solubility through stable folding and reduced intermolecular contacts.

The paper shows that proteins in cell-like environments reduce RNA folding stability by passively suppressing base pairing, altering RNA structure predictions.

This study shows that aminoacyl-RNA loop-closing ligation is stereoselective, favoring L-amino acids over D-amino acids, and suggests this process could have contributed to the emergence of homochirality in amino acids.

This study describes an autocatalytic assembly pathway that generates a chimeric aminoacyl-RNA synthetase ribozyme capable of self-sustaining and assembling other ribozymes.

The paper shows that specific RNA sequences can be nonenzymatically aminoacylated and ligated to form amino acid-bridged stem-loop RNAs, with structural and functional similarities to modern tRNA.

This paper investigates the thermodynamic and kinetic effects of coaxial stacking and dangling ends on RNA complex stability and binding kinetics.