Author

Chuhan Geng

Broad InstituteORCID 0000-0001-7779-6172Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Assay:bulk RNA-seq· 4 Research Focus:differential expression· 4 Organism:mouse· 4 Approach:statistical model· 4 Research Focus:gene regulatory network inference· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2

Frequent Co-Authors

Bryan J. SongiD· 4 shared Hasmik KeshishianiD· 4 shared Morgan ShengiD· 4 shared Sameer AryaliD· 4 shared Steven A. CarriD· 4 shared Zohreh FarsiiD· 4 shared Ally A. NicolellaiD· 3 shared Antia Valle-TojeiroiD· 3 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Bryan J. SongORCID

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4 papers

Recent·Most cited

NeuroscienceNature CommunicationsPeer-reviewedNov 28, 2025

Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder

Bryan J. Song, Yang Ge, Ally A. Nicolella…·Morgan Sheng

This study investigates Akap11 mutant mice to explore the neurobiological effects of AKAP11 loss, finding increased PKA activity and transcriptomic changes linked to schizophrenia and bipolar disorder.

17 citationstop 1%

mousebulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintFeb 18, 2025

Epigenetic changes, neuronal dysregulation and metabolomic abnormalities in Zmym2 mutant mice, a genetic model of schizophrenia and neurodevelopmental disorders

Wei-Chao Huang, Kira A. Perzel Mandell, Sameer Aryal…·Morgan Sheng

2 citations

mousebulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintOct 12, 2024

Muti-omics characterization reveals brain-wide disruption of synapses and region- and age-specific changes in neurons and glia in Sp4 mutant mice, a genetic model of schizophrenia and bipolar disorder

Min Jee Kwon, Kira A. Perzel Mandell, Sameer Aryal…·Morgan Sheng

This study uses multi-omics analyses of Sp4 mutant mice to reveal synapse disruption and age- and region-specific neuronal and glial changes linked to schizophrenia and bipolar disorder.

2 citations

mousebulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintOct 10, 2024

SRRM2 haploinsufficiency drives SynGAP-γ reduction, Agap3 mis-splicing, and oligodendrocyte deficits in a mouse model of schizophrenia

Sameer Aryal, Chuhan Geng, Margaret A. Yin…·Morgan Sheng

This study shows that SRRM2 haploinsufficiency in mice causes synaptic, splicing, and myelination defects linked to schizophrenia-like behaviors and gene expression changes.

5 citations

mousebulk RNA-seq

𝕏 PostBluesky