Jan Frič

This study shows sepsis causes long-term changes in human HSPCs, leading to immune dysregulation in survivors through altered myeloid progeny and metabolic reprogramming.

This study shows ERK3 promotes TNBC progression through EMT plasticity and collective migration, linking it to poor clinical outcomes.

This study shows serotonin reduces inflammation in intestinal tissue by altering monocyte behavior and chemokine expression using a human 3D model.

This study examines long-term immune changes post-COVID-19 and the impact of BCG vaccination and latent infections on disease severity.

This study identifies IL-26-expressing MAIT cells as protective for epithelial barrier function and shows their dysregulation in Crohn's disease.