Rosemary E. Kiernan

The paper shows that nuclear RNA exosome complexes regulate enhancer-promoter interactions by modulating ncRNA levels and cohesin binding.

This study identifies NRDE2 interactions with transcription and splicing factors and shows its broad impact on gene expression and splicing in human cells.

The paper identifies PAP-gamma as a component of the PAXT complex that recruits it to gene promoters, regulating PROMPT ncRNA abundance through polyadenylation.

The paper identifies NF90's interaction with RISC components and shows it modulates Ago2-mRNA association and mRNA stability during hypoxia.

The paper identifies the MRN complex's role in protecting actively transcribing genes from genomic instability through transcriptional association.

The paper shows NF90 modulates processing of a subset of human pri-miRNAs by binding to stable intronic structures, increasing mature miRNA abundance when NF90 is lost.