Author

Marion Helsmoortel

Centre National de la Recherche ScientifiqueORCID 0000-0002-2702-5318Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Rosemary E. KiernaniD· 4 shared David DepierreiD· 3 shared Olivier CuvieriD· 3 shared Xavier ContrerasiD· 3 shared Alexandre HeurteauiD· 2 shared Charbel AkkawiiD· 2 shared Giuseppa Ida GrassoiD· 2 shared Kader SalifouiD· 2 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersMolecular Biology

Rosemary E. KiernanORCID

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4 papers

Recent·Most cited

Nuclear exosome targeting complexes modulate cohesin binding and enhancer-promoter interactions in 3D

Charbel Akkawi, Alexandre Heurteau, Xavier Contreras, Marion Helsmoortel, Stéphane Schaak, Julie Bossuyt, Olivier Fosseprez, David Depierre, Olivier Cuvier, Rosemary E. Kiernan

The paper shows that nuclear RNA exosome complexes regulate enhancer-promoter interactions by modulating ncRNA levels and cohesin binding.

Nature Communications · Aug 6, 2026Peer-reviewedMolecular Biology

PAP-gamma associates with PAXT nuclear exosome to control the abundance of PROMPT ncRNAs

Xavier Contreras, David Depierre, Charbel Akkawi, Marina Srbić, Marion Helsmoortel, Maguelone Nogaret, Matthieu Le Hars, Kader Salifou, Alexandre Heurteau, Olivier Cuvier, Rosemary E. Kiernan

The paper identifies PAP-gamma as a component of the PAXT complex that recruits it to gene promoters, regulating PROMPT ncRNA abundance through polyadenylation.

Nature Communications · Oct 24, 2023Peer-reviewedMolecular Biology

Chromatin-associated MRN complex protects highly transcribing genes from genomic instability

Kader Salifou, Callum Burnard, Poornima Basavarajaiah, Marion Helsmoortel, Victor Mac, David Depierre, Giuseppa Ida Grasso, Céline Franckhauser, Emmanuelle Beyne, Xavier Contreras, Jérôme Déjardin, Sylvie Rouquier, Olivier Cuvier, Rosemary E. Kiernan

The paper identifies the MRN complex's role in protecting actively transcribing genes from genomic instability through transcriptional association.

Science Advances · May 21, 2021Peer-reviewedMolecular Biology

NF90 Modulates Processing of a Subset of Human Pri-miRNAs

Giuseppa Ida Grasso, Takuma Higuchi, Victor Mac, Jérôme Barbier, Marion Helsmoortel, Claudio Lorenzi, Gabriel Sanchez, Maxime Bello, William Ritchie, Shuji Sakamoto, Rosemary E. Kiernan

The paper shows NF90 modulates processing of a subset of human pri-miRNAs by binding to stable intronic structures, increasing mature miRNA abundance when NF90 is lost.

Nucleic Acids Research · May 1, 2020Peer-reviewedMolecular Biology