GeneticsbioRxivPreprint
The WD40 domain of autophagy protein ATG-16.2 is required for lysosomal regulation and longevity in germline-less C. elegans
Hiroshi Ebata, Sahiba K. Dogra, Ling-Hsuan Sun…·Malene Hansen
DOI 10.64898/2026.10.14.758959
Author
University of California, San FranciscoORCID 0000-0001-6664-2389Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Hiroshi Ebata, Sahiba K. Dogra, Ling-Hsuan Sun…·Malene Hansen
Mackenzie Welch, Paul J. Sampognaro, Shunpan Shu…·Aimee W. Kao
The paper identifies PQLC2 as a lysosomal pH regulator that affects tau homeostasis through a CRISPRi screen in iPSC-derived neurons.
Molly Hodul, Courtney Lane‐Donovan, Emily S. Cheang…·Aimee W. Kao
This study identifies multiple cathepsins and progranulin that regulate prosaposin cleavage into saposins, which are critical for sphingolipid metabolism.