Malene Hansen

AA-20 promotes lipophagy by activating lysosomal acid lipase and CDK5, reducing lipid droplet accumulation and improving neurodegeneration-associated phenotypes in cellular and organoid models.

This study shows senescent cells release chromatin components via extracellular particles, activating inflammation in neighboring cells and being present in aged mice.

This paper shows that food deprivation in C. elegans reduces repellent sensitivity, mediated by intestinal transcription factors and insulin signaling to neurons, leading to riskier behaviors.

This study shows that neuropeptides regulate intestinal integrity and aging in invertebrates, with effects modulated by the germline.

This study shows that LC3B phosphorylation by STK4 regulates FYCO1 binding and directional transport of autophagosomes, switching their movement from retrograde to anterograde under starvation conditions.