Developmental BiologybioRxivPreprint
Ampk activation by glycogen expenditure primes the exit of naive pluripotency
Seong-Min Kim, Eun‐Ji Kwon, Jiyoung Oh…·Hyuk‐Jin Cha
The paper shows that glycogen depletion activates Ampk in naive ESCs, promoting their transition to a primed state by reducing fatty acid synthesis and altering pluripotency markers.
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