Goo Jang

This paper develops FATE, a mutation-agnostic base-editing platform that rescues HGPS phenotypes in neuromuscular organoids by disrupting the LMNA farnesylation motif.

This study shows that Cyp17a1 knockout in rats leads to obesity with increased subcutaneous fat, but without metabolic syndrome due to improved subcutaneous fat metabolism.

The paper shows that glycogen depletion activates Ampk in naive ESCs, promoting their transition to a primed state by reducing fatty acid synthesis and altering pluripotency markers.

This paper develops a genetic barcode system using a Cas9-deaminase to trace cell lineage in mammals, showing accurate reconstruction of lineage from bulk and single-cell data.