Keun-Tae Kim

This study identifies Mtf2 as an epigenetic barrier that maintains naive pluripotency by restricting trophectoderm competence in embryonic stem cells.

The paper shows that glycogen depletion activates Ampk in naive ESCs, promoting their transition to a primed state by reducing fatty acid synthesis and altering pluripotency markers.

The paper establishes isogenic GNE myopathy disease models using base editors in hPSCs, showing mutation-specific hyposialylation and drug responses.

The paper develops a method to enrich genome-edited human pluripotent stem cells by inducing temporary drug resistance through SLC35F2 knockdown, achieving efficient selection in 3 weeks.