Ampk activation by glycogen expenditure primes the exit of naive pluripotency
Seong-Min Kim, Eun‐Ji Kwon, Jiyoung Oh, Han Sun Kim, Sunghyouk Park, Goo Jang, Jeong Tae, Keun-Tae Kim, Hyuk‐Jin Cha
The paper shows that glycogen depletion activates Ampk in naive ESCs, promoting their transition to a primed state by reducing fatty acid synthesis and altering pluripotency markers.
bioRxiv · May 19, 2023 · PreprintDevelopmental Biology