Eric R. Cole

The paper uses in vivo imaging to show that cortical spreading depolarization depletes endoplasmic reticulum calcium, linking ER dynamics to seizure suppression.

This paper develops an active learning framework to personalize brain stimulation therapies, showing it outperforms random sampling in efficiency and accuracy across in silico and in vivo experiments.

SAFE-OPT is a Bayesian optimization algorithm that incorporates safety constraints to find optimal deep brain stimulation parameters without harmful side-effects, validated in rodent studies.

This study evaluates optogenetic stimulation waveforms on hippocampal spectral activity, finding that irregular patterns better mimic natural activity than standard pulses.

This paper introduces an automated algorithm to detect seizure-related events in calcium imaging data, showing accurate detection of pre-ictal spikes and seizure wave propagation in mice.

This study develops and evaluates adaptive Bayesian optimization for state-dependent brain stimulation, showing it can find optimal parameters even when neural states are unknown or unmeasurable.