Lorenzo Stufera Mecarelli

The paper identifies late endosomes as selective RNA carriers in motor neurons and shows that ALS-linked FUS mutations disrupt this process.

The paper uses Pepper fluorescent RNA to visualize and study the dynamics of circRNAs and lncRNAs in live cells, revealing their interactions with pathological aggregates and stress granules.

This study examines how ALS-associated FUS mutations alter the RNA and protein composition of Stress Granules in neural cells, revealing molecular changes linked to neurodegeneration.