Andrea Giuliani

This study shows that mutant FUS reduces ALKBH5 expression, increasing m6A levels, and that restoring m6A alleviates ALS pathology in Drosophila models.

This study identifies a 63-nucleotide element that promotes efficient circRNA translation, comparable to traditional IRESs, enhancing their therapeutic potential.

This study examines how ALS-associated FUS mutations alter the RNA and protein composition of Stress Granules in neural cells, revealing molecular changes linked to neurodegeneration.

The paper shows that reducing m6A content via METTL3 knock-down decreases FUS-associated ALS granules in cell models and patient-derived fibroblasts.

This study identifies Dbx2 as a gene that inhibits adult neural progenitor proliferation and is downregulated in the aged SVZ niche.