Author

Alexander Pietras

Lund UniversityORCID 0000-0002-5783-9347Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2

Frequent Co-Authors

Rebecca RosbergiD· 3 shared Bengt PhungiD· 2 shared Crister P CebergiD· 2 shared David LindgreniD· 2 shared Dimitra Manou· 2 shared Elinn JohanssoniD· 2 shared Goran B JönssoniD· 2 shared Jonas SjölundiD· 2 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Rebecca RosbergORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Coevolution of neoplastic and non-neoplastic reactive astrocyte states converges on mesenchymal-like and injury-response programs during murine glioblastoma progression and post-radiotherapy recurrence

David Lindgren, Rebecca Rosberg, Karolina I. Smoląg, Elinn Johansson, Dimitra Manou, Jonas Sjölund, Sebastian Benedict Braun, Bengt Phung, Katja Harbst, Pauline Jeannot, Maria Malmberg, Crister P Ceberg, Goran B Jönsson, Kristian Pietras, Alexander Pietras

The paper maps transcriptional changes in astrocyte and tumor cell states during glioblastoma progression and recurrence, identifying reactive astrocyte-like tumor cells associated with radioresistance.

bioRxiv · Dec 22, 2025 · PreprintCancer Biology

Pericytes orchestrate a tumor-restraining microenvironment in glioblastoma

Sebastian Braun, Paulina Bolívar, Clara Oudenaarden, Jonas Sjölund, Matteo Bocci, Katja Harbst, Mehrnaz Safaee Talkhoncheh, Bengt Phung, Eugenia Cordero, Rebecca Rosberg, Elinn Johansson, Goran B Jönsson, Alexander Pietras, Kristian Pietras

This study identifies pericytes as a key paracrine signaling hub in glioblastoma that restrains tumor progression by modulating the tumor microenvironment and immune response.

Nature Communications · Dec 4, 2025Peer-reviewedCancer Biology

Phenotypic Screening Identifies Flunarizine as an Inhibitor of Radiotherapy-Induced Astrocyte Reactivity with Therapeutic Potential in Glioblastoma

Pauline Jeannot, Rebecca Rosberg, David Lindgren, John C. Dawson, Enrico Pracucci, Cornelia Börjesson Freitag, Julia Martinez, Vasiliki Pantazopoulou, Maria Malmberg, Karolina I. Smoląg, Dimitra Manou, Richard J. R. Elliott, Crister P Ceberg, Tracy J. Berg, Henrik Ahlenius, , Alexander Pietras

This paper identifies Flunarizine as a compound that inhibits radiation-induced astrocyte reactivity and improves survival in a glioblastoma model.

bioRxiv · Jul 12, 2025 · PreprintCancer Biology