Won‐Mo Yang

This study identifies LRP1 as a mediator of leptin transport across the blood-CSF barrier in the choroid plexus, coupled with the short-form leptin receptor, and shows its deletion leads to leptin resistance and obesity.

This study shows that deleting LRP1 in GABAergic neurons causes memory impairments and obesity in mice, linking LRP1 function to metabolic and cognitive health.

This study identifies ROCK1 as a mediator of melanocortin's anorexigenic effect through a novel signaling pathway involving G12 and AMPK suppression.