Vincent Prévot

This study shows that Gαq/11 signaling in brain endothelial cells prevents endothelial dysfunction and cognitive decline in aged mice by maintaining vascular reactivity and preventing blood-brain barrier disruption.

This study shows that tanycytic cilia sense metabolic cues in the cerebrospinal fluid, affecting energy balance and metabolism in mice.

This study creates a novel mouse model with deletion of Necdin and Magel2 genes, revealing functional interactions and phenotypes relevant to Prader-Willi Syndrome.

The paper investigates SARS-CoV-2 infection in the hypothalamus and associated regions, showing viral entry receptors and susceptibility factors linked to neurological symptoms in COVID-19.

This study identifies LRP1 as a mediator of leptin transport across the blood-CSF barrier in the choroid plexus, coupled with the short-form leptin receptor, and shows its deletion leads to leptin resistance and obesity.

This study shows that deleting LRP1 in GABAergic neurons causes memory impairments and obesity in mice, linking LRP1 function to metabolic and cognitive health.

This study demonstrates that gene therapy targeting brain endothelial cells improves neurological symptoms in a mouse model of MCT8 deficiency by increasing brain T3 levels and motor function.

This study shows that selective ablation of adult hypothalamic GFAP-expressing tanycytes causes hypogonadotropic hypogonadism in males by reducing GnRH neurons and testosterone levels.