Aykut Göktürk Üner

The paper identifies IRF3 as a key transcriptional regulator of leptin's hunger-suppressing effects in AgRP neurons through integrated genomic analysis.

This study identifies LRP1 as a mediator of leptin transport across the blood-CSF barrier in the choroid plexus, coupled with the short-form leptin receptor, and shows its deletion leads to leptin resistance and obesity.

This study shows that deleting LRP1 in GABAergic neurons causes memory impairments and obesity in mice, linking LRP1 function to metabolic and cognitive health.