Author

Karina Ramalho Bortoluci

Universidade de São PauloORCID 0000-0001-6780-5397Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Amanda Verdicchio Caniato· 1 shared Luiza Zainotti Miguel Fahur BottinoiD· 1 shared Mariana de Jesus Dias· 1 shared Rafael Queiroz de SouzaiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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1 shared paperImmunology

Amanda Verdicchio Caniato

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1 paper

Recent·Most cited

Opposing roles of GSDMD and NINJ1 shape early IL-1β dependent host defense during Toxoplasma gondii infection

Rafael Queiroz de Souza, Amanda Verdicchio Caniato, Luiza Zainotti Miguel Fahur Bottino, Mariana de Jesus Dias, Karina Ramalho Bortoluci

This study shows that GSDMD limits host resistance to Toxoplasma gondii while NINJ1 promotes protection, revealing opposing roles of pyroptotic effectors in IL-1β-dependent immunity.

bioRxiv · Jun 1, 2026 · PreprintImmunology