Guoming Gao

The paper quantifies VCP hexamer assembly and subunit exchange dynamics, showing that the R155H mutation impairs ASPL-mediated exchange, potentially stabilizing mutant VCP in assemblies.

The paper uses live-cell tracking to show that hyperosmotic stress causes HOPS condensates to exhibit sub-diffusion due to ER tethering and super-diffusion via microtubule transport.

This study uses single-molecule tracking to show that nanodomains within FUS condensates regulate diffusion and aging, influencing fibrilization and disease progression.

This study shows surface tethering improves accuracy in measuring diffusion within 3D protein condensates by reducing motion artifacts while preserving their native properties.