ASPL-driven subunit exchange remodels VCP/p97 hexamers and is impaired by a multisystem proteinopathy mutation
Jingxuan Tang, Laxmikanta Khamari, Benjamin J. T. Dodd, Guoming Gao, Liuhan Dai, Stephanie L. Moon, Nils G. Walter
The paper quantifies VCP hexamer assembly and subunit exchange dynamics, showing that the R155H mutation impairs ASPL-mediated exchange, potentially stabilizing mutant VCP in assemblies.
bioRxiv · May 8, 2026 · PreprintBiophysics