Author

Shinichi Hirose

Fukuoka UniversityORCID 0000-0001-6796-3790Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Kaori KubotaiD· 2 shared Katsunori Iwasaki· 2 shared Kouya UchinoiD· 2 shared Masanobu Deshimaru· 2 shared Shutaro KatsurabayashiiD· 2 shared Takuya WatanabeiD· 2 shared Yasuyoshi TanakaiD· 2 shared Adrian Walton MooreiD· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersNeuroscience

Kaori KubotaORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

NeuroscienceScientific ReportsPeer-reviewedMay 17, 2022

CUX2 deficiency causes facilitation of excitatory synaptic transmission onto hippocampus and increased seizure susceptibility to kainate

Toshimitsu Suzuki, Tetsuya Tatsukawa, Genki Sudo…·Kazuhiro Yamakawa

This study identifies CUX2 and CASP variants in temporal lobe epilepsy patients and shows they increase seizure susceptibility and excitatory synaptic transmission.

13 citations

humanmouse

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NeuroscienceScientific ReportsPeer-reviewedMay 20, 2021

Inhibitory synaptic transmission is impaired at higher extracellular Ca2+ concentrations in Scn1a+/- mouse model of Dravet syndrome

Kouya Uchino, Hiroyuki Kawano, Yasuyoshi Tanaka…·Shinichi Hirose

This study shows that inhibitory synaptic transmission is impaired in Scn1a+/- mice, with reduced inhibitory synapses and increased sensitivity to extracellular Ca2+.

15 citations

mouseelectronic health records

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NeurosciencebioRxivMay 18, 2021

Astrocyte Ca2+ Signaling is Facilitated in an Scn1a+/- Mouse Model of Dravet Syndrome

Kouya Uchino, Yasuyoshi Tanaka, Wakana Ikezawa…·Shinichi Hirose

This study shows that astrocyte Ca2+ signaling is enhanced in Scn1a+/- mice, suggesting a role for astrocytic Ca2+ dysregulation in Dravet syndrome pathogenesis.

10 citations

mouseexperimental assay

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