Markus F. Neurath

This study identifies a neuroimmune IL-13 axis involved in human enteric nervous system development through transcriptomic and functional analyses of neonatal ileum tissue.

This study shows TNF-α disrupts the malate-aspartate shuttle in iPSC-derived enteric neural cells from PD patients, causing metabolic shifts and mitochondrial dysfunction, which can be reversed by targeting glutamate metabolism.

This study identifies IBD type-associated EGC activation signatures and reveals TNF/IFN-γ-driven necroptosis of activated enteric glia in inflammatory bowel diseases.

The paper compares 13 mouse models of intestinal inflammation with human IBD datasets to identify translatable pathways and introduces a web tool for analyzing these models.

This study integrates multi-omic and multimodal data from IBD patients to identify molecular, histopathological, and clinical features associated with inflammatory bowel diseases.

This study improves detection of extracellular mRNAs using modified small RNA-sequencing, revealing their potential as biomarkers and showing increased resolution in disease states.