Claudia Günther

This study identifies a neuroimmune IL-13 axis involved in human enteric nervous system development through transcriptomic and functional analyses of neonatal ileum tissue.

This study shows TNF-α disrupts the malate-aspartate shuttle in iPSC-derived enteric neural cells from PD patients, causing metabolic shifts and mitochondrial dysfunction, which can be reversed by targeting glutamate metabolism.

This study identifies IBD type-associated EGC activation signatures and reveals TNF/IFN-γ-driven necroptosis of activated enteric glia in inflammatory bowel diseases.

This study identifies ZEB1 as a key regulator of TAM-mediated T cell trafficking, enhancing CTL recruitment and immunosurveillance in tumors and metastases.

The paper compares 13 mouse models of intestinal inflammation with human IBD datasets to identify translatable pathways and introduces a web tool for analyzing these models.

This study integrates multi-omic and multimodal data from IBD patients to identify molecular, histopathological, and clinical features associated with inflammatory bowel diseases.

The paper identifies the Feret diameter as a reliable quality marker for brain organoids and shows mesenchymal cells negatively impact organoid formation.

This paper develops an immortalized human lacrimal gland epithelial cell line for studying dry eye disease mechanisms and potential treatments.