Peng Xue

This paper develops an ITO-PET slide that enables sequential MALDI-MSI and LCM-LC-MS analysis of the same tissue section, demonstrating comparable performance to conventional slides across multiple tissues.

The paper introduces a multi-omics framework to analyze protein activity in context-specific networks, demonstrating its utility in linking molecular profiles to phenotypic outcomes using HeLa and Kyoto cell lines.

This study identifies PKM1-regulated PEP metabolism as a key factor in improving functional maturation of human stem-cell derived β cells by enhancing calcium response and insulin secretion.

DIP-MS resolves protein complex isoforms using deep learning and mass spectrometry, revealing new subunits in human prefoldin complexes.

The paper presents a rapid workflow combining experimental and computational methods to profile protein complex re-organization in cellular states, showing distinct changes during differentiation and macrophage stimulation.

SECAT quantifies differential protein-protein interaction states across cellular states by analyzing PPI networks, showing improved scalability and effectiveness over previous methods.

The paper introduces PCprophet, a computational framework for identifying and analyzing protein complexes from co-fractionation mass spectrometry data across conditions.