Xun Chen

DSMBind predicts binding energy and designs nanobodies without experimental data, achieving performance comparable to supervised models.

This paper introduces OpenAWSEM and Open3SPN2, GPU-accelerated coarse-grained simulation tools for proteins and DNA, enabling faster and more flexible modeling of biomolecular systems.

The paper uses ribosome profiling in Drosophila to show post-translational mechanisms drive retrograde signaling in presynaptic efficacy, with no transcriptional or translational changes required.