Zhou Gong

This study shows that the ATAD2 BRD mediates liquid-liquid phase separation to enhance histone acetylation and promote gene expression.

This study shows chaperones modulate enzyme activity in native states, expanding their role beyond protein folding.

This paper identifies functional hotspots in large enzymes using a hybrid NMR-computational approach, enabling efficient directed evolution with targeted mutagenesis.

This study uses atomic-level simulations to show how ligand binding modulates conformational dynamics of the M2 muscarinic receptor, revealing key aromatic residue interactions involved in activation.

This study demonstrates how the oligopeptide (FK)4 enables the determination of absolute stereochemistry of chiral compounds using NMR spectroscopy by combining alignment medium and chiral differentiating properties.